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GRASP Lab Seminar 2003-2004
October 10, 11:00 AM, Levine Hall 307, hosted by George Pappas.
Bud Mishra
NYU
Cell Talk
Abstract: Freeman Dyson, in his 1985 Tarner Lectures, asked: "Is Life one thing or two things? Is there a logical connection between metabolism and replication?".
As the study of the genomes and proteomes have become amenable to computational analysis to decipher "part-lists" of life (e.g. genes, mRNA's, proteins, promoters, etc.), it may now be possible to address Dyson's questions with algorithmic tools based on dynamical systems, control theory and computational logic to study complex metabolic pathways. This talk introduces the concept of algebraic differential automata (ADA) systems to model biological processes, and how we plan to use them to interpret experimental data modulated by regulatory, metabolic and intercellular signaling processes.Biography: Prof. Mishra has a degree in Physics from Utkal University, in Electronics and Communication Engineering from IIT, Kharagpur, MS and PhD degrees in Computer Science from Carnegie-Mellon University. He has industrial experience in Computer Science (Tartan Laboratories) and Finance (Tudor Investment and PRF, LLC) and is a founder of a biotechnology company, Opgen, Madison, Wisconsin. His research has ranged from compilers, algorithms and complexity, logic, and algebra to robotics, finance and biology.His most recent research work is at the interface of computer science and biology. He has developed several sophisticated algorithms and statistical analysis tools to attack biological problems that range from deciphering the genome of pathogens (E. coli, P. falciparum, etc.) to understanding chromosomal aberrations that are implicated in cancer.
